Karthika was born to actress Radha and hotelier Rajasekharan Nair and is the niece of actress Ambika. She has two siblings, a brother and a sister. She did her studies in Podar International School in Mumbai and is now studying for an international degree in Business from a college affiliated to London School of Economics. She made her debut in the 2009 Telugu film, Josh opposite Naga Chaitanya. She is now appearing in the Malayalam film Makaramanju directed by Lenin Rajeendran alongside ace cinematographer and director Santosh Sivan. She is also working on K. V. Anand\'s Ko which will mark her Tamil debut.It was released on 22.4.2011 and is marked as a hit in the tamil film industry.
